Teaching Methodologies
Expository theoretical classes using audiovisual and interactive means between student and teacher, using theoreticalpractical classes to reinforce the understanding of theoretical syllabus and its application in the laboratory matrix.
Two hours a week are available, with a pre-defined time or to be arranged with the student to clarify doubts.
Each student is also given the pedagogical support of all the material taught or the bibliographical references
recommended for the discipline, at the beginning of the semester.
Continuous assessment: Theoretical and practical attendance
Students will have to obtain an assessment equal to or greater than 10 in practical frequency and 9.5 in theoretical frequency.
The final grade is obtained by the weighted average of the two corresponding matrices.
Theoretical matrix 65%; practical matrix 35%
Students are admitted to the exam, taking into account the specifications of the Academic Regulation.
Learning Results
The curricular unit of Analytical Chemistry in Pharmacy I aims to provide the student with an adequate knowledge of theoretical principles, qualitative and quantitative analysis, practical components and application of instrumental methods of analysis, indispensable to the performance of laboratory activities, with the main objective of applying new technologies to the field of Pharmacy, its validation, quality control, as well as in the area of Pharmaceutical Industry and research. Knowledge of GLP, GMP and ICH systems in the analysis of medicines in quality control, as well as compliance with quality specifications, identification, purity, dosage; role of Pharmacopoeia monographs and reference substances.
Program
Theoretical matrix
1. Ultraviolet-visible spectroscopy;
2. Infrared spectroscopy;
3. Nuclear magnetic resonance spectroscopy;
4. Atomic absorption and emission spectroscopy;
5. Capillary electrophoresis;
7.Chromatography;
8. High Performance Liquid Chromatography (HPLC) Ultra Performance Liquid Chromatography (UPLC);
10. Sample preparation methods.
Theoretical-practical matrix
Application of theoretical concepts in the practical laboratory matrix; performing calculations for preparing solutions, identifying the method of analysis according to the role of monographs and reference substances of Pharmacopoeias, GMP, GLP and ICH; treatment of experimental/graphic and statistical data and critical analysis.
Practical matrix
1. UV-Visible Spectroscopy;
2. Chromatography;
3- Solid phase extraction and recovery tests.
Curricular Unit Teachers
Internship(s)
NAO
Bibliography
-Skoog D.A., Nieman T.A., Holler F.J., Princípios de Análise Instrumental, 5ª edição, Bookman
– Pombeiro A.J.L.O. Técnicas e operações unitárias em química laboratorial. 2ª ed. Fundação Calouste Gulbenkian. Lisboa 1991
– Farmacopeia Portuguesa – IX Edição
– http://www.infarmed.pt e documentos que aí se encontram.
– http://www.ich.org e documentos que aí se encontram.
– http://www.fda.gov/ e documentos que aí se encontram.
– http://www.ema.europa.eu/ema/ e documentos que aí se encontram.
– https://ec.europa.eu/health/documents/eudralex/vol-4_en e documentos que aí se encontram.