Immunology

The teaching and evaluation methodologies had been designed to allow the students to develop a complete knowledge in the immunology field and are aligned with the curricular unit objectives. The unit will have 2 moments of evaluation, one consisting in a presentation about food and immune system (10% of the final classification) and a writing evaluation (90% of the final classification)

He student should acquire the knowledge of:
•Innate and acquired immunity.
•Cells of the immune system and soluble mediators.
•Lymphopoiesis. Primary and secondary lymphoid organs.
•Phases of the immune response.
•Antigen processing and presentation.
•Chemokines and cell migration.
•Effectors mechanisms of the immune response.
• Diseases of the Immune system.
Therapies that interfere with the immune system.
New anti-tumoural therapies.
The student should acquire the faculty of:
•Identify changes in cellular or humoral immunological parameters in a normal or abnormal context.
The student should acquire the skills to:
•Develop, retain and expand their knowledge in the Immunology field.
•Know the cells and the soluble mediators involved during an immune response in a normal or pathological condition.
Understand the mechanism of action of the therapies that interfere with the immune system

An overview of the immune system: Innate and acquired immunity; cells and soluble mediators.
Different phases of an immune response.
Lymphoid system: Lymphopoiesis; Primary and secondary lymphoid organs; Cell migration.
Antigens, antibodies and cell receptors.
Immunogenetics: Major histocompatibility complex; inflammatory genes.
Antigen recognition by the immune system. Antigen processing and presentation.
Cell cooperation during a cellular or humoral immune response. Cytokines and chemokines.
Effectors mechanisms of an immune response: immunocomplex, complement activation, cellular and antibody dependent cell cytotoxicity.
Immune response regulation and tolerance induction.
Immune response to virus, bacteria and tumor.
Physiopathology of autoimmune diseases, primary immunodeficiency´s and of allergy.
Therapies that interfere with the immune system.

NAO

GORDON REEVES AND IAN TODD – LECTURE NOTES ON IMMUNOLOGY
IVAN ROITT – IMMUNOLOGY
PETER PARHAM – O SISTEMA IMUNE
FERNANDO AROSA – FUNDAMENTOS EM IMUNOLOGIA
KUBY – IMMUNOLOGY