Oncobiology

Cellular and Molecular Biology, Immunology, Morphological Pathology, Biochemistry,

Expository method using audiovisual media. It also includes an autonomous study with research on the exposed contents.

To understand the concept of neoplasia as alteration of growth and differentiation of cells / tissues;

Recognize the main types of human neoplasia, their geographical distribution and temporal evolution; Identify
the main phases of neoplastic development and the agents involved in this process; Recognize the foundations
molecular / genetic factors underlying the process of tumorogenesis; Recognize the process of tumorogenesis as
interaction between organism and environment; Recognize and understand the main associated hereditary conditions
cancer; Know the therapies used to fight cancer; Know the main techniques used in
Oncobiology.
Understand the basic mechanisms of therapy aimed at molecular targets; Recognize the main
fields and lines of research in Oncobiology

1. Know and understand the concept of neoplasia as an alteration of growth and differentiation of cells / tissues;

2. Identify the main stages of neoplastic development and the agents involved in this process;

3. Recognize the molecular / genetic bases underlying the process of tumorigenesis;

4. Recognize the role of the microenvironment in the tumorigenesis process

5. Know and identify the main types of human neoplasia, their geographical distribution and temporal evolution;

6. Know and understand the main hereditary conditions associated with cancer;

7. Know the therapies used to fight cancer;

8. Understand the basic mechanisms of therapy aimed at molecular targets;

9. Know and understand the lines of research in Oncobiology

Contents

1 Intercellular communication and signal transduction pathways;

1 Cell proliferation and aging;

1 Cell cycle;

1 Proteins regulating cell proliferation; Telomeres and telomerase;

1-3, 8 Angiogenesis;

1-3.8 Apoptosis;

1 Tumor growth biology;

5 Epidemiology;

3 Molecular bases of cancer;

2 Carcinogens;

2, 3 Phases of tumor growth;

1, 2, 3 Invasion and Metastasis;

1, 2, 3 Tumor stem cells;

5 Classification of tumors;

7-9 Therapeutics: proteins as a therapeutic target;

7 – 9 Resistance to therapy;

1-3, 8 Tumor markers;

NAO

Primary reference

– DEVITA, Vincent T., Jr.; LAWRENCE, Theodore S.; ROSENBERG, Steven A., ed. lit. – Devita, Hellman, and Rosenberg’s cancer: principles & practice of oncology. 10th edition. Philadelphia, [etc.]: Wolters Kluwer, cop. 2015. xiv, 2234 p. ISBN 978-1-4511-9294-0

– ABELOFF, Martin D., ed. lit. – Abeloff’s clinical oncology. 4th ed. Philadelphia, PA: Churchill Livingstone / Elsevier, cop. 2008. xxx, 2555 p. ISBN 978-0-443-06694-8

– DAVIES, A. M.; SUNDARAM, M.; JAMES, S. L. J.; ANDERSON-SEMBACH, S.; BAERT, A. L., ed. lit. Imaging of bone tumors and tumor-like lesions: techniques and applications. Berlin; Heidelberg: Springer, cop. 2009. XII, 698 p. ISBN 978-3-540-77982-7

– KOSS, Leopold G.; ; MELAMED, Myron R., ed. lit. – Koss’ diagnostic cytology and its histopathologic bases. 5th ed. Philadelphia; Baltimore: Lippincott Williams & Wilkins, cop. 2006. 2 vol. (xviii, 1752, I-52 p.). ISBN 978-0-7817-1928-5.

Secondary reference

– PECORINO, Lauren – Molecular Biology of Cancer: Mechanisms, Targets and therapeutics. 3rd edition

– Hanahan, D.; Weinberg, R.A. The Hallmarks of Cancer. Cell 2000, 100, 57–70, doi:10.1016/S0092-8674(00)81683-9.

-Hanahan, D.; Weinberg, R.A. Hallmarks of Cancer: The Next Generation. Cell 2011, 144, 646–674, doi:10.1016/j.cell.2011.02.013.

– Soerjomataram, I.; Bray, F. Planning for tomorrow: global cancer incidence and the role of prevention 2020–2070. Nat. Rev. Clin. Oncol. 2021, 18, 663–672, doi:10.1038/s41571-021-00514-z.