Pharmacy Aseptic Technology

Pharmacokinetics and Pharmacodynamics

Organization and functioning of the hospital and community pharmacy

1. The theoretical component comprises more expository classes using audiovisual means but promoting interactivity between teacher and students;

2. The practical component is based on practical simulation work on the preparation of chemotherapy protocols, parenteral nutrition and other aseptic protocols.

It is intended that at the end of this course the students have acquired abilities in planning and structuring of compounding sterile and non-sterile preparations services, combining the financial/to quality and safety in the handling and preparation of galenic formulations economic aspects.

Identify the skills and procedures of aseptic techniques that lead to quality at all stages of handling non-sterile and sterile medicines.
Identify the assumptions that underlie the assessment of patients on Chemotherapy and Parenteral Nutrition.
Awareness and responsibility for the high degree of complexity of some activities associated with handling cytotoxic and parenteral nutrition.
Identify all stages of handling and preparation of parenteral nutrition and chemotherapy protocols.
Adequately aseptic techniques for preparing intravenous admixtures in the hospital pharmacy service.

MODULE 1 (4h): DRUG HANDLING IN THE HOSPITAL PHARMACY – PHARMACOTECHNICS

1.1- HANDLING NON-STERIL MEDICINE

Importance and purposes

Physical structure

Non-sterile dosage forms

1.2- HANDLING OF STERIL MEDICINES:

Importance and purposes

Physical structure

International guidelines for the sterile handling of medicinal products for human use

MODULE 2 (4h): DISINFECTION & STERILIZATION

2.1- DISINFECTION

Definition and types of disinfection

Criteria and uses of disinfectants:

Precautions and risks

Decontamination

Disinfectant classification

2.2- STERILIZATION

Sterilization Methods:

Physical Agents

Chemical Agents

MODULE 3 (8h): ONCOLOGY

3.1- TYPES OF TREATMENT in ONCOLOGY

3.1.1- Local therapy:

Surgery

Radiotherapy

Intervention Radiology

3.1.2- Systemic therapy:

Chemotherapy:

History of chemotherapy

Chemotherapy concept

Chemotherapy goals

Classification and Mechanism of Action of Cytostatics (e.g. Alkylating Agents, Antimetabolites, Vinca Alkaloids and Taxanes, Antitumor Antibiotics, Topoisomerase-I and -II Inhibitors)

Other Medicines:

Hormone therapy (e.g. Anti-estrogens; Aromatase inhibitors)

Immunotherapy (e.g. interferons, interleukins, monoclonal antibodies)

Targeted therapeutics (e.g. Drugs targeting growth factor receptors: anti-HER and anti-IGF-1R)
 

3.2-CYTOSTATIC PREPARATION UNIT – CHEMOTHERAPY

Manipulation of cytostatics

administration of cytostatics

Cytostatic Reconstitution Service: Centralized Unit in the Pharmacy (UPC)

 
 MODULE 4 – (6h)

4- PARENTERIC NUTRITION

4.1 History and concept

4.2 Definition, objectives and indications

4.3 Hospital malnutrition

4.3.1 Causes of hospital malnutrition

4.4 Types of parenteral nutrition

4.5 Routes of administration of parenteral nutrition

4.5.1 Superficial venous system

4.5.2 Deep venous system

4.6 Complications of n. FOR.:

4.6.1 Mechanics

4.6.2 Infectious

4.6.3 Metabolic

4.7 Stability of nutritional mixtures
 

 MODULE 5 – (4h)

5- QUALITY CONTROL OF STERIL AND NON-STERIL PRODUCTS MANUFACTURED IN PHARMACOTECHNICS

5.1- TOXIC AND NON-TOXIC PRODUCTS AND WASTE RESULTING FROM PHARMACOTECHNICS

5.1.1- Hospital waste

5.1.2- Waste classification – legislation

5.1.3- Disposal of medical waste

5.1.4- Elimination of excreta

NAO