Tecnologia e Farmácia Galénica II

Basic notions of safety in a laboratory environment;

Basic rules and techniques of laboratory work;

Knowledge of material and equipment in common use in laboratories;

Knowledge of standards for weighing and measuring volumes and temperature of liquids;

Elementary knowledge of mechanical operations of separation and division of solids.

Theoretical lectures using audiovisual and interactive means between students and teacher.

In the theoretical-practical classes, students carry out a bibliographic research work in groups of three students, and present it in the form of a poster.

Practical classes, in a group of two students, with preparation of different galenic forms.

At the end, students must master the terminology, concepts and technical-scientific aspects inherent to medicines and pharmaceutical technology of dosage forms. It is intended to enable the student with fundamental knowledge about the pharmaceutical forms addressed in relation to the operations to which the substances are subjected, the properties of the products used, the composition, application and preparation procedures and quality control. In the practical component, the student must be able to autonomously apply rational and scientific methods for the formulation and preparation of dosage forms, to interpret the formula, to know how to associate the substances, the incompatibilities that may arise and the fundamental aspects of labeling , conservation and storage of the prepared formulas. Know the main pharmaceutical forms suitable for modifying the release of drugs and their important therapeutic and/or diagnostic applications.

THEORETICAL PROGRAM
1. Dosage forms obtained by mechanical dispersion
   1.1. Suspensions
   1.2. Colloidal dispersions
   1.3. Complementary forms of suspensions
      1.3.1 Aerosols
2. Dosage forms obtained by molecular dispersion: solutions
   2.1. Simple solutions
   2.2. Hydro oils: hydrolytes and extractive solutions
   2.3. Liquid saccharoils: syrups and mellitus
   2.4. Alcohols: alcoholites, elixirs, tinctures and alcoholics
   2.5. Glycerols
   2.6. Ether oils
   2.7. Eoils
   2.8. Acetoles
   2.9. Oils
3. Pharmaceutical Forms obtained by dissolution and evaporation
   3.1. Extracts
4. Pharmaceutical Forms obtained by complex or multiple operations
   4.1. For application to the skin
      4.1.1. Ointments themselves
      4.1.2. Creams
      4.1.3. Folders

      4.1.4. Gels or jellies ointments
      4.1.5. Liniments
      4.1.6. Lotions
      4.1.7. Soaps
      4.1.8. Plasters, poultices and synapisms
      4.1.9. Ophthalmic ointments

      4.1.10 transdermal preparations
   4.2. Preparations for ear use
   4.3. Preparations for application to mucous membranes
      4.3.1. Suppositories
      4.3.2. Ovules
      4.3.3. Preparations for ophthalmic use
      4.3.4. Preparations for nasal use
      4.3.5. Preparations for urethral use
   4.4. Pharmaceutical Forms for Parenteral Use
      4.4.1. Injectable preparations

5. Controlled release pharmaceutical forms – concepts, requirements and advantages: Liposomes, nanoparticles, microencapsulation, micelles and microemulsions.

THEORETICAL-PRACTICAL PROGRAM
1. Suspensions: theoretical and practical aspects of your preparation
   1.1. Suspending and wetting agents
   1.2. Preparation of suspensions
2. Solutions: theoretical and practical aspects of their preparation
   2.1. Preparation of hydrolytes
   2.2. Preparation of alcoholites
   2.3. Glycerites preparation
   2.4. Saturated solutions
   2.5. Syrup preparation
3. Ointments: theoretical and practical aspects of their preparation
   3.1. Preparation of ointments themselves
   3.2. Cream preparation
   3.3. Preparation of folders
   3.4. Gel preparation
   3.5. Preparation of ophthalmic ointments
   3.6. Preparation of cerates
4. Lotions: theoretical and practical aspects of their preparation
5. Soaps: theoretical and practical aspects of their preparation
6. Suppositories: theoretical and practical aspects of their preparation
   6.1. Fusion preparation

PRACTICAL PROGRAM
1. Preparation of the following dosage forms:
   1.1. Suspensions
   1.2. Solutions
      1.2.1. Hydrolytes
      1.2.2. Alcoholites
      1.2.3. Glycerites
   1.3. Syrups
   1.4. Ointments
      1.4.1. Ointments themselves
      1.4.2. Right
      1.4.3. O/W and A/O creams
      1.4.4. Dermal Pastes
      1.4.5. gels
      1.4.6. ophthalmic ointments
   1.5. Lotions
   1.6. Soaps
   1.7. Suppositories

NAO

Farmacopeia Portuguesa IX – INFARMED I.P. / Ministério da Saúde

Farmacopeia Portuguesa IV – Imprensa Nacional Casa da Moeda

Técnica farmacêutica e farmácia galénica – L. N. Prista, A. C. Alves, R. M. R. Morgado – Fundação Calouste Gulbenkian

Tecnologia farmacêutica – L. N. Prista, A. C. Alves, R. M. R. Morgado – Fundação Calouste Gulbenkian

Formulário Europeu de Medicamentos – INFARMED I.P. / Ministério da Saúde

Formulário Galénico Português. Cetmed. ANF

Prontuário Terapêutico – INFARMED / Ministério da Saúde 

Pharmacie galénique – A. Le Hir – Paris: Masson

Handbook of Pharmaceutical Excipients. London: The Royal Pharmaceutical Society of Great Britain and the American Pharmaceutical Association

Manual de Terapêutica Dermatológica e Cosmetologia. Aureliano da Fonseca, L. Nogueira Prista. São Paulo: Roca

Noções de Farmácia Galénica. A. Le Hir. São Paulo: Organização Andrei Editora

Manipulação Magistral de Medicamentos em Pediatria – Gilberto Barcelos Souza. Ed.: Pharmabooks

The merck índex: an encyclopedia of chemicals, drugs and biologicals – Susan Budari – New Jersey: Merck & Co.

Pharmaceutics: The Science of Dosage Form Design. M. E. Aulton. Churchill Livingstone. 

Química medicinal: as bases moleculares da acção dos fármacos – E. J. Barreiro, C. A. M. Fraga – Porto Alegre: Artmed

Remington – A Ciência e a Prática da Farmácia. Alfonso R. Gennaro. 

Abrégé de Pharmacie Galénique– Le  Hir

Enciclopedia Farmaceutica – Del Pozo

Guia Prático da Farmácia Magistral: Farmacotécnia, Boas práticas de manipulação, Controle de Qualidade, Aspectos Biofarmacêuticos, Excipientes e veículos, Procedimentos operacionais padrão. Anderson de Oliveira Ferreira, Pharmabooks

Teoria e Prática na Indústria Farmacêutica. I e II Volume. Serviço de Educação e Bolsas. Fundação Calouste Gulbenkian. Leon Lachman; Herbert A. Lieberman; Joseph L. Kanig

Boas Práticas de Fabrico de Manipulados. Despacho nº 18/91 – D. R. Série II nº 209 (11-9-1991)

Martindale – The Complete Drug Reference. Pharmaceutical Press