Toxicology in Human Health

Presentation and debate of relevant theoretical-practical concepts in the classroom; Guidance on the autonomous study of students by consulting the recommended bibliography; Discussion and reflection on relevant issues related to the subject exposed in the classroom and presentation and discussion of case studies that reinforce theoretical learning. Preparation of practical work that allows the consolidation of knowledge and learning in the field.
Theoretical-practical assessment – 65%
Practical assessment – 35% with class work
(Minimum scores of 9.5 values in each of the matrix)
Exam assessment according to academic regulations

THE STUDENT MUST ACQUIRE KNOWLEDGE OF:
Toxicology and ecosystems
Influence of Toxicology on the human environment
Influence of the toxicological effect on human health
THE STUDENT MUST ACQUIRE SKILLS TO:
Recognize and identify contamination factors
Recognize the possible effects of toxics on ecosystems
Routes of entry and distribution in the body
THE STUDENT MUST ACQUIRE COMPETENCES TO:
Develop identification and toxicological control plans
Develop plans for Mitigation, control and toxicological reduction
Control and combat toxicological effects on Human Health

Introduction to Environmental Toxicology and Ecotoxicology
Concepts in Toxicology and Human Health
Contamination and Pollution
– Emerging problems
– Current challenges
Characterization, distribution and movement of environmental toxics
Toxicological indicators, bioindicators and sentinel species
Dose-response relationship
Exposure to toxics
– Absorption pathways
– Distribution
– Detoxic metabolism and excretion
Dynamic drug: general mechanisms of action, target organs
Non-target organ toxicity
Factors Affecting Toxicity
Bioaccumulation and biomagnification
Main classes of environmental toxic agents and their mechanisms of action
– Metals
– Organic compounds: Pesticides, Dioxins, Polychlorinated Biphenyls, Polycyclic Aromatic Hydrocarbons
– Endocrine disruptors
– Organic solvents
– Others
Environmental contamination biomarkers
– Exposure
– Effects
– Susceptibility
Ecotoxicity assessment methods and Risk assessment
Nanotechnology and health effects

NAO

BORREGO, Carlos, ed. lit. – Investigação em ambiente e saúde [Brochura]: desafios e estratégias. Aveiro: Universidade de Aveiro, 2009. 98 p. ISBN 978-972-789-288-4.
DUVIGNEAUD, Paul – A síntese ecológica. 2ª ed. rev. e corrigida. Lisboa: Instituto Piaget, D.L. 1996. XXXVI, 786 p. ISBN 978-972-8245-43-2.
FERRAZ, Ana Isabel ; RODRIGUES, Ana Cristina – Biotecnologia : ambiente e desenvolvimento sustentável. [1ª ed.]. Porto : Publindústria, cop . 2011. xvii, 283, [3] p. ISBN 978-972-8953-81-2.
WALKER, C. H. [et al.] – Principles of ecotoxicology. 3rd ed. Boca Raton; London; New York: Taylor & Francis, 2006. xxiii, 315 p. ISBN 978-0-8493-3635-5.
IZRAEL, Yu. A. – Ecology and control of the natural environmemt. Dordrecht: Klumer Academic Publishers, 1992. X, 420 p. ISBN 0-79231197-3.
Manual de contaminación ambiental. Madrid: Mapfre, 1994. XIV, 578 p. ISBN 84-7100-957-9.