Fundamentals of Bioprocesses

General knowledge of mathematics, chemistry and physics.

The theoretical-practical classes have an expository component and theoretical-practical component where the students apply theoretical knowledge in solving and discussing problems with direct application to concepts taught,  under the guidance of the lecturer.

In the practical laboratory classes, the fundamentals of the experimental work to be done are presented and discussed, and students are encouraged to do a previous reading of the recommended bibliography. A critical analysis of the obtained results will be done, and written reports will be prepared to develop critical thinking skills and the capacity for synthesis.

The formal lectures will be complemented by periods of individual attendance.

The course aims to provide students with general knowledge of the principle of mass conservation, in particular how it applies to molecular species and to the total mass of a given system. Procedures for solving the system of equations resulting from the application of the principle of mass conservation to systems operating in steady-state and without chemical reaction are also be addressed. Using the technological laboratories of ESAC, the course allows the practical application of the concepts taught. On a personal level, the course will help students to develop autonomous and critical thinking.

A. Theoretical component

1. Systems of units. Base and derived quantities. Most common systems of units. Prefixes of the units of the International System. Unit conversion factors.

2. Thermodynamic concepts. Notion of system, border and neighborhood. Open system and closed system. Discontinuous, semi-continuous and continuous processes. Steady state and transient state. System in equilibrium.

3. Principle of mass conservation. Positive and negative accumulation. Global and partial mass flow and molar flow.

4. Application of the principle of mass conservation to the total mass of a system and to the mass of an atomic, molecular species or biomass. Application to processes without chemical reaction and in steady state.

5. Approaches to solving mass balance problems: definition and analysis of the problem, calculation of unknown quantities and finalization.

B. Theoretical-practical and laboratory component

Resolution of mass balance problems: processes with mixture and separation of currents, processes with recycling of currents and with transfer of matter between two currents, in co-current and counter-current.

Laboratorial practice to demonstrate the concepts taught, namely: 1) Mixing processes; 2) Drying processes: in an oven, in an air flow dryer and in a freeze dryer; 3) Evaporation processes; 4) Separation processes by filtration: conventional filtration, ultrafiltration and reverse osmosis; 5) Separation process by centrifugation.

• - Teste teórico 100 - 100.0%

• - Teste teórico 30 - 30.0%
• - Teste teórico 50 + relatórios 50 - 70.0%

NAO

Himmelblau, D.; Riggs, J. (2012). Basic Principles and Calculations in Chemical Engineering (8th ed.). New Jersey: Prentice Hall,  ISBN13: 978-0-13-234660-3.

Shuler, M.; Kargi, F.; Delisa, M. (2017). Bioprocess Engineering: Basic Concepts (3rd ed.). Boston: Prentice Hall, ISBN13: 978-0137062706.

Duncan, A. (2011). Introduction to Chemical Engineering Processes (1st ed.). Delhi: Global Media, ISBN: 978-93-80168-32-6.

Doran, P.  (2004). Bioprocess Engineering Principles. London: Academic Press, ISBN: 978-0122208515.