Introduction to Bioengineering

Not applicable.

Lecture (T) classes will be targeted at understanding the theoretical foundations of the course, being complemented with practical (TP) classes for resolution of questions. In lecture classes the theoretical concepts exposition will be performed by Powerpoint slides projection. In the practical classes the different chapters exercise sheets are solved and group works analysis of scientific papers on issues related to Bioengineering is performed. Students are encouraged to participate with questions and comments during both lecture and practical classes. At the end of the practical classes it will be discussed the answers to the questions posed and framed topics. All study material is made available through the Moodle platform.

The main objective of this course is to provide students with an integrated view of Bioengineering and its various fields of application, focused on the analysis of engineering concepts, biological systems and processes design. It is intended that the students be able to: i) understand the concepts of the new engineering and life sciences paradigms, and identify the current areas of technological importance, including synthetic biology, Nanobiotechnology, industrial and environmental biotechnology processes, molecular and cellular therapies, regenerative medicine and gene therapy; ii) perform mass and energy balances within biological processes; iii) analyze, layout and define processes and their variables; iv) identify business opportunities through innovative processes.

1. Bioengineering as the result of the integration of physical sciences, engineering and life sciences. Introduction to bioprocesses. Recombinant DNA technology. The era of genomics, proteomics and metabolomics. Synthetic biology. Nanobiotechnology. Bioprocess engineering. Industrial, environmental and energy applications. Molecular and cellular therapies and regenerative medicine.
2. Introduction to engineering calculations. Process definition. Process variables. Manufacturing diagrams, flow charts and block diagrams.
3. Introduction to mass balances. Mass balances processes with and without reaction. Stoichiometry of cell growth and product formation.
4. Energy balances. Types of energy. Energy conservation equation. Energy balances on non-reaction processes.
5. Innovation and entrepreneurship.

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NAO

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Doran, P., Bioprocess Engineering Principles, 2nd Ed., Elsevier, 2012.

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Bailey, J.E., Ollis, D.F., Biochemical Engineering Fundamentals. , McGraw-Hill., 1987.

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Cortassa, S., Aon, M.A., Iglesias, A.A., Lloyd, D., An introduction to metabolic and cellular engineering. World Scientific Publishing Co. Pte. Ltd, 2002.

Seider, W.D., Seader, J.D., Lewin, D.R., Product and process design principles, 2008. ISBN: 0-471-45247-5 0471203165.

Neumann, K-H., Kumar, A., Imani, J., Plant cell and tissue culture – a tool in biotechnology, Springer-Verlag Berlin Heidelberg, 2009.