Base Knowledge
Applied Organic Chemistry, Inorganic Chemistry and Laboratory Techniques in Pharmacy
Teaching Methodologies
Expository theoretical classes using audiovisual and interactive means between student and teacher, using
theoreticalpractical classes to reinforce the understanding of theoretical syllabus and its application in the
laboratory matrix.
Two hours a week are available, with a pre-defined time or to be arranged with the student to clarify doubts.
Each student is also given the pedagogical support of all the material taught or the bibliographical references
recommended for the discipline, at the beginning of the semester.
Learning Results
The curricular unit of Analytical Chemistry in Pharmacy I aims to provide the student with an adequate knowledge of theoretical principles, qualitative and quantitative analysis, practical components and application of classical methods and instrumental methods of analysis, indispensable to the performance of laboratory activities, with the main objective of applying new technologies to the field of Pharmacy, its validation, quality control, as well as in the area of Pharmaceutical Industry and research. Knowledge of GLP, GMP and ICH systems in the analysis of medicines in quality control, as well as compliance with quality specifications, identification, purity, dosage; role of Pharmacopoeia monographs and reference substances.
Program
Theoretical matrix
1. Introduction to analytical chemistry;
2. Errors in analytical chemistry;
3. Introduction to drug quality control;
4. Laboratory accreditation and certification;
5. Calibration methods;
6. Sampling;
7. Method validation;
8. Volumetric methods;
8. Gravimetric methods;
9. Electrochemical methods.
Theoretical-practical matrix
Application of theoretical concepts in the practical laboratory matrix; performing calculations for preparing solutions, identifying the method of analysis according to the role of monographs and reference substances of Pharmacopoeias, GMP, GLP and ICH; treatment of experimental/graphic and statistical data and critical analysis.
Practical matrix
1. Qualitative and quantitative analysis of drugs
2. Volumetric analysis
3. Direct Potentiometry and Potentiometric Titrations
Curricular Unit Teachers
Ana Paula Gomes FonsecaInternship(s)
NAO
Bibliography
Primary Bibliography
-Skoog D.A., Nieman T.A., Holler F.J., Princípios de Análise Instrumental, 5ª edição, Bookman
– Pombeiro A.J.L.O. Técnicas e operações unitárias em química laboratorial. 2ª ed. Fundação
Calouste Gulbenkian. Lisboa 1991
– Farmacopeia Portuguesa – IX Edição-http://www.infarmed.pt
Secondary Bibliography
– http://www.ich.org
– http://www.fda.gov/
– http://www.ema.europa.eu/ema/
– https://ec.europa.eu/health/documents/eudralex/vol-4_