Base Knowledge
Knowledge in cellular and molecular biology
Teaching Methodologies
The main goal of theoretical classes is to present in detail all the different parts of the program. During the classes, graphic exposition, based on powerpoint presentations, will be used to allow a better acquisition of knowledge by the students, as well as a good interaction between the students and the teacher.
During the theoretical-practical part of the immunology classes, it will be emphasized the discussion of clinical cases.
Learning Results
The student should acquire the knowledge of:
•Innate and acquired immunity.
•Cells of the immune system and soluble mediators.
•Lymphopoiesis. Primary and secondary lymphoid organs.
•Phases of the immune response.
•Antigen processing and presentation.
•Chemokines and cell migration.
•Effectors mechanisms of the immune response.
• Diseases of the Immune system.
Therapies that interfere with the immune system.
New anti-tumoural therapies.
The student should acquire the skills to:
•Develop, retain and expand their knowledge in the Immunology field.
•Know the cells and the soluble mediators involved during an immune response in a normal or pathological condition.
Understand the mechanism of action of the therapies that interfere with the immune system.
Program
An overview of the immune system: Innate and acquired immunity; cells and soluble mediators.
Different phases of an immune response.
Lymphoid system: Lymphopoiesis; Primary and secondary lymphoid organs; Cell migration.
Antigens, antibodies and cell receptors.
Immunogenetics: Major histocompatibility complex; inflammatory genes.
Antigen recognition by the immune system. Antigen processing and presentation.
Cell cooperation during a cellular or humoral immune response. Cytokines and chemokines.
Effectors mechanisms of an immune response: immunocomplex, complement activation, cellular and antibody dependent cell cytotoxicity.
Immune response regulation and tolerance induction.
Immune response to virus, bacteria and tumor.
Physiopathology of autoimmune diseases, primary immunodeficiency´s and of allergy.
Therapies that interfere with the immune system.
Anti-tumoural therapies.
Curricular Unit Teachers
Artur Augusto PaivaInternship(s)
NAO
Bibliography
Primary:
DELVES, Peter J. [et al.] – Roitt’s essential immunology. 11th ed. Malden ; Oxford ; Victoria : Blackwell, 2006. XVI, 474 p. ISBN 978-1-4051-3603-7.
ROITT, Ivan M. – Essential immunology. 4th ed. Oxford[etc.] : Blackwell Scientific Publications : cop.1980. XVI, 358 p. ISBN 0-632-00739-7.
AROSA, Fernando A. ; CARDOSO, Elsa M. ; PACHECO, Francisco C., ed. lit. – Fundamentos de imunologia. 2ª edição atualizada e aumentada. Lisboa : Lidel, cop. 2012. XXIV, 615 p. ISBN 978-972-757-856-6.
AROSA, Fernando A. ; CARDOSO, Elsa M. ; PACHECO, Francisco C. – Fundamentos de imunologia. Lisboa ; Porto : Lidel, cop. 2007. XXXII, 339 p. ISBN 978-972-757-396-7.
Secondary:
Jenni Punt; Sharon Stranford; Patricia Jones; Judy Owen – Kubi Immunology. 8th ed. Macmillan, 2019. ISBN:9781319172985