Immunology

Teaching Methodologies

To achieve the learning objectives and ensure the development of the intended competencies, the teaching/learning process includes:

1. Expository theoretical classes are supported by audiovisual materials (videos, PowerPoint), discussion of articles, and thematic research presentations, allowing the lecturer to assess student progression.

2. Laboratory practical classes involving the execution of techniques and field classes (animal production units), including collection of animal-derived samples (blood, feces) from mammals and birds.

3. Tutorial sessions where student learning and task completion involve direct collaboration with the lecturer.

Learning Results

The objective of this course unit is to provide students with fundamental knowledge of basic immunology and to develop practical skills related to the technological application of these concepts, namely in diagnostic techniques, immunization, and other related areas.

Competencies:

1. Identify and describe the components of the immune system and their functions.

2. Explain the mechanisms of cellular interaction involved in innate and adaptive immune responses.

3. Perform immunological laboratory techniques.

4. Explain the theoretical principles underlying the techniques performed and interpret and critically evaluate the results.

Program

Module 1 – Components of the Immune System

  1. Infectious agents and antigenic determinants
  2. Lymphoid organs: primary and secondary
  3. Barriers and nonspecific mechanisms of the immune response (Innate immunity): inflammatory process, phagocytic cells, Natural Killer (NK) cells, dendritic cells, complement system, opsonins and receptors
  4. Major Histocompatibility Complex and histocompatibility molecules
  5. T and B lymphocytes
  6. Immunoglobulins and cytokines

Module 2 – Immune System Response

  1. Antigen processing and presentation: cells involved and mechanisms
  2. Cellular and humoral immune responses
  3. Mucosal protection mechanisms
  4. Immunity transfer
  5. Vaccines and vaccination
  6. Primary and secondary immune responses

Practical Component

  1. Collection of biological samples
  2. Immunological techniques: theoretical principles, practical execution, interpretation of results, and evaluation of diagnostic quality

Curricular Unit Teachers

Manuela Andreia Gonçalves Carneiro

Internship(s)

NAO

Bibliography

Arosa F., Cardoso, E.M., Pacheco, FC. Fundamentos de Imunologia. LIDEL, 2007. ISBN 978-972-757-396-7.

Artigos vários: Immunobiology ISSN: 0171-2985; Microbes and Infection ISSN: 1286-4579; Veterinary Immunology and Immunopatology Veterinary Parasitology ISSN: 0304-4017.

Current Protocols in Immunology (Wiley, 2018). [E-Reader Version]. Online ISBN: 9780471142737. DOI: 10.1002/0471142735. Retrieved from https://currentprotocols.onlinelibrary.wiley.com/loi/1934368.

Gerald N. Callahan, Robin M. Yates (2014). Basic Veterinary Immunology. University Press of Colorado, p.337. ISBN 1607322188, 9781607322184.

TIZARD, Ian R. Veterinary immunology: an introduction. 6th ed. Philadelphia: W. C. Saunders Company, Cop. 2000. ISBN 0-7216-8218-9.

Yuan, S., Tao, X, Huang, S., Chen,S., Xu, A. (2014). Comparative Immune Systems in Animals. Annual Review of Animal Biosciences. Vol. 2:235-258. https://doi.org/10.1146/annurev-animal-031412-103634