Clinical-Laboratorial Hematology I

As aulas teóricas visam a apresentação detalhada dos conteúdos programáticos. Nelas se utiliza uma metodologia
expositiva-ativa, apelativa da intervenção direta dos alunos, favorecendo assumidamente uma iconografia
abundante em detrimento do ensino meramente teórico-descritivo.
Na vertente prática do ensino da Hematologia privilegia-se, a análise de casos englobando morfologia,
fenotipagem, parâmetros hematimétricos e alterações genéticas, o que vai permitir a elaboração de um possível
diagnóstico e classificar as diferentes hemopatias malignas.

The student should acquire the knowledge of:
• Normal Hematopoiesis and their regulation.
• Malignant hematopoietic disorders: Etiology, Physiopathology, WHO classification, Diagnosis methods, prognosis
and treatment monitoring.
• Laboratory methods in Hematology: Hematimetric parameters, morphology, phenotype, molecular biology,
conventional cytogenetic and fluorescence in situ hybridization.
The student should acquire the skills of:
• Well known the normal and malignant hematopoiesis.
The student should acquire the competences of:
• Develop, retain and expand their knowledge in the Hematology field.
• Know the different WHO entities, starting in the etiology of each disease, physiopathology and clinical and
biological characteristics.
• Know the laboratorial methodologies more often used to do a correct diagnosis of the different hematological
neoplasm and to analyze the obtained results in normal or pathological conditions.

Hematological malignancies overview: The importance of the lab for diagnosis, prognosis and treatment
monitoring.
Hematimetric parameters: normal and abnormal values and their correlation with different disorders.
Normal hematopoiesis: Phenotypic and morphological changes during the maturation process in all hematological
lineages.
B, T and NK chronic lymphoproliferative disorders: Etiology; physiopathology; molecular, phenotypic and
morphological diagnosis. Treatment.
Monoclonal gammopathies: Etiology; physiopathology; molecular, phenotypic and morphological diagnosis.
Treatment.
B or T acute lymphoblastic leukemia’s: Etiology; physiopathology; molecular, phenotypic and morphological
diagnosis. Treatment.
Acute myeloblastic leukemia’s and other acute leukemia’s: Etiology; physiopathology; molecular, phenotypic and
morphological diagnosis. Treatment.
Dendritic cells neoplasm: Etiology; physiopathology; molecular, phenotypic and morphological diagnosis.
Treatment.

NAO