Base Knowledge
Knowledge of general biochemistry, chemistry and cell biology.
Teaching Methodologies
The theoretical classes are aimed at the detailed presentation of the program contents. Use an
expositoryactive methodology, appealing the direct intervention of the students.
In the practical component part of the curricular unit it’s privileged the execution of practical laboratory
assignments, explanations and discussion of clinical cases.
Learning Results
The student must acquire knowledge of:
• Theoretical foundations underlying the metabolism of carbohydrates, amino acids and proteins;
• Laboratory parameters indicated for the diagnosis and monitoring of pathologies associated with
alterations of metabolism.
The student must acquire skills:
• Understand the laboratory parameters indicated for the diagnosis and monitoring of pathologies
associated with metabolic changes, in order to be possible to provide clinically relevant laboratory
information;
The student must acquire competences of:
• Understand the various pathologies associated with changes in the metabolism of carbohydrates,
aminoacids and proteins;
• Select the laboratory parameters indicated in diagnosis and/or monitoring of these pathologies;
• Validate and interpret critically the results obtained.
Program
Renal function:
-Acid-base balance;
-Water-electrolytes balance;
-Endocrine Function;
-Laboratory evaluation and associated pathologies.
Metabolism of carbohydrates:
-Hypo and hyperglycaemia system;
-Diabetes and its acute complications and chronic;
-Laboratory Assessment and associated pathologies.
Amino acids metabolism:
-Laboratory evaluation and associated pathologies. Protein metabolism:-specific proteins;
-Laboratory evaluation of hepatic function and associated pathologies;
-Laboratory evaluation of muscle and heart diseases.
Curricular Unit Teachers
Armando José Cerejo CaseiroGrading Methods
The continous evaluation comprehend a theoretical component that include a written assessment (50%) and
the presentation of a group project on a topic of the in the program contents (20%), as well as practical
component that will be evaluated by a report on practical activities (30%).
In each evaluation moment the student must obtain a minimum of 9.5 values to be approved. Students who have achieved a minimum final grade of 10 values in the curricular unit are approved.
The report on practical activities will be done individually in a template provided by the teachers, during a
previously scheduled practical class, dealing with an pratical laboratorial activity performed by the student
and framed in the topics taught in the curricular unit.
The student can perform the evaluation of the curricular unit by exam.
Internship(s)
NAO
Bibliography
Primary bibliography:
Ahmed, Nessar, ed. lit. – Clinical biochemistry. Second edition. Oxford : Oxford University Press, cop. 2017.
Burtis, CA; Bruns, DE, Sawyer, BG, Tietz, NW. Tietz fundamentals of clinical chemistry and molecular diagnostics. seventh edition. ed. St. St. Louis, Mo: Elsevier/Saunders, cop. 2015.
Gaw, Alan et al – Clinical Biochemistry: An Illustrated Colour Text. 5th ed. Churchill-Livingstone Elsevier, 2013.
Kaplan, Lawrence; Pesce, Amadeo – Clinical Chemistry: Theory, Analysis, Correlation: With 509 Illustrations and 25 Color Plates. 5th ed. St. Louis, Mo.: Mosby/Elsevier, 2010.
Secondary bibliography:
Murphy, Michael, et al – Clinical Biochemistry: An Illustrated Colour Text. 6th ed. Churchill-Livingstone Elsevier, 2019.
Rifai, N., et al., Tietz fundamentals of clinical chemistry and molecular diagnostics. Eighth edition. ed. St. Louis, Missouri: Elsevier, 2019.
Bishop, M.L., E.P. Fody, and L.E. Schoeff, Clinical chemistry : principles, techniques, and correlations. Eighth edition. ed. Philadelphia: Wolters Kluwer, 2018.
Mcpherson, Richard; Pincus, Matthew; Henry, John – Henry’s Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia: Saunders Elsevier, 2011.
Devlin, Thomas M – Textbook of Biochemistry with Clinical Correlations. 7th ed.: Wiley, 2010
Pimentel, Rui A. Medicina Laboratorial: Estados Inflamatórios – Da prescrição à interpretação clínica. Vol. 3. Lisboa: Lidel, out. 2024.
Pimentel, Rui A. Medicina Laboratorial: Química Clínica e Endocrinologia – Da prescrição à interpretação clínica. Vol. 4. Lisboa: Lidel, dez. 2024.