Clinical-Laboratorial Molecular Pathology

Expositor and appealing methodology for direct intervention by students using audiovisual media. In addition, there is also the autonomous study with research on some of the described contents.
The knowledge assessment includes an individual written test, with a weight of 80% and a group work with 20% with a minimum grade of 9 (nine) values, at each time of assessment. The approval results from the weighted average of the evaluation moments with a final grade equal to or higher than 10 points.
The assessment can also be carried out by written exam with a structure identical to the written exam at the times designated for that purpose in the academic calendar.

Clinical-Laboratorial Molecular Pathology aims to study the molecular basis of the disease, in conjunction with the support of laboratory tools in the diagnosis, prognosis and monitoring of the pathology.
The student must:
Characterize and evaluate the main pathologies at the molecular levei.
Identity the notions of molecular biology and molecular genetics applied to inherited diseases.
Identity the possible risk factors as a positive and negative modulating effect.
Recognize the multiple methodologies and select the most appropriate for each pathology.
Correlate clinicai severity with various types of mutations and establish a genotype-phenotype correlation. Plan the collection and handling of biological samples according to the study objectives.
Select, plan and evaluate molecular methods and techniques to be applied according to diagnosis, prognosis, therapeutic indication and investigation.

– Pathology and molecular genetics
– Genotoxicity
– Molecular mechanisms of cell regulation
– Diagnosis, prognosis and therapeutic indication in human pathology – Liquid biopsy and circulating tumor DNA
Evaluation of the molecular profile and biomarkers in the diagnosis and monitoring of the molecular changes and pathologies mentioned below:
– Disorders in lipid and carbohydrate metabolism
– Autoimmune pathology
– Nenie pathology: Alzheimer’s disease, Parkinson’s disease, epilepsy – Oncological pathology
– Anemias
– Hereditary hemochromatosis
– Hemoglobinopathies: beta thalassemia, hemoglobin C, hemoglobin S
– Thrombophilia: annexin A5, Apo E, Factor V Leiden, MTHFR, prothrombin – Warfarin sensitivity/resistance

NAO