Program
1. Cell Biology
a. Cell – Structure and Function
b. Cell Cycle
c. Cell death
d. DNA Damage and Repair
Radiobiology
2. Physical and chemical principles of radiation interactions with matter
a. Physical, chemical and biological phases
b. Linear energy transfer
c. Direct and indirect effects of radiation
3. Cellular and Molecular Radiobiology
a. Radiation effect on DNA and Cell Cycle
b. Stochastic and Deterministic Effects
c. Relative biological efficiency
d. Bystander effect
e. Radioprotective and Radiation-Sensitizing agents
f. 5 Rs
g. Effect of Oxygen
h. Oxygen enhancement ratio
4. Survival Curves and Models
a. Single-target, single-hit model
b. Multitarget, single-hit model
c. Two-component model
d. Linear-quadratic model
e. Lethal-potentially lethal damage model
f. Linear-quadratic-cubic model
5. Radiation effects on Normal Tissues
a. Acute Effects
b. Chronic Effects
6. Radiation effects on Embryonic Development
7. Heritable radiation effects
Internship(s)
NAO
Bibliography
Michael Joiner, Albert van der Kogel – Basic Clinical Radiobiology Fourth Edition,
Hodder Education, 2009
Steve Forshier – Essentials of Radiation, Biology and Protection, Cengage Learning, 2nd Edition 2009
A. H. W. Nias – An Introduction to Radiobiology, Jonh Wiley and Sons, 2nd Edition. 1998
Eric J. Hall, Amato J. Giaccia – Radiobiology for the Radiologist Lippincott Williams & Wilkins, 2012
Radiobiology for the Radiologist. HALL, E.J. e GIACCIA, A.J. Philadelphia: Lippincott Williams & Wilkins, 6a Ed.
2006.