Teaching Methodologies
A theoretical expository methodology will be adopted which appeals for the students’ participation to acquire the knowledge,skills and competences defined so that they can be put into practice. Summary evaluation will be done test and/or assessmentby examination.
Theoretical-Practical assessment by continuous assessment during TP classes and by a work to be presented at the end of thesemester and Theoretical by frequency and / or exam. The TP component will count 30% and the theoretical 70% for the finalclassification, each of which may not be less than 9.5 values.
Learning Results
The student must acquire knowledge of:
• Radiopharmaceuticals used in professional practice including pharmacokinetics and pharmacodynamics, dosing, theassociated risks and the associated legal regulations
• Quality control procedures associated with Radiopharmaceuticals.
• Pharmacological interactions and adverse reactions of drugs and radiopharmaceuticals
• Minimizing dose in humans and the environment
• Operation of a Radiopharmaceutical, including legal regulation, operations and registration.
The skills in safely managing the radiopharmaceutical, including bodkin and administration according with the active protocol.
Competences to responsibly and autonomously perform professional tasks for the patient at the time of theradiopharmaceutical administration, respond appropriately to contraindications, complications and emergencies. When it isappropriate should create radiopharmaceutical within the existing policies and standards.
Program
Introduction to Radiopharmaceuticals and fundamental principles. Basic notions of Radiopharmaceutical. (4h)Radiopharmaceuticals in Nuclear Medicine. Diagnosis vs. therapy. Types of formulation. Molybdenum-technetium generator.Technetium chemistry-99m. Properties of chelation and bio conjugated. Main applications in conventional MN. Marking ofantibodies and peptides. Marking of cells.(8h)
Radiopharmaceuticals marked with Positron emitters. Main clinical applications and research. (6h)
Quality control in radiopharmaceuticals. Conventional Radiopharmaceuticals vs PET. Good radiopharmaceuticals practice .Analytical procedures. Process control. Microbiological tests.(6h)
Radiopharmaceuticals Operation. European and national regulations. Work in aseptic environment. Organization of a productionunit. Validation, documentation and archive. (6h)
Internship(s)
NAO
Bibliography
Abrunhosa, Antero and Prata, Maria I. (2010). Radiopharmaceuticals: Development and Main Applications. in Nuclear MedicinePhysics. Pedroso de Lima, J.J. (Ed.). CRC Press;
Saha, Gopal B. (2018). Fundamentals of Nuclear Pharmacy. Springer-Verlag. Seventh Edition.
Theobald, Tony (2010), Sampson’s Textbook of Radiopharmacy. Pharmaceutical Press. Fourth edition; Handbook ofRadiopharmaceuticals: Radiochemistry and Applications (2005). Michael J. Welch (Ed). Wiley.