Nuclear Pharmacy

Basic knowledge of Chemistry, Biochemistry, Physiology and Pharmacology as lectured in the other curricular units of the course.

A theoretical methodology will be adopted which appeals for the students’ participation to acquire the knowledge, skills and competences defined so that they can be put into practice and a theoretical-practical methodology that focus on the application of the acquired knowledge to practical examples in Radiopharmacy.

The student must acquire the fundanental knowledge of Radiopharmaceuticals used in the medical practice
including pharmacokinetics and pharmacodynamics, dosing, the risks and the associated legal regulations

• Introduction to Radiopharmaceuticals and fundamental principles. Basic notions of Radiopharmaceuticals.
• Radiopharmaceuticals in Nuclear Medicine. Diagnostic vs. therapy. Types of formulations. Molybdenum/Technetium generator. Technetium-99m chemistry. Properties of chelates and bio-conjugated materials. Main applications in conventional NM. Labeling of antibodies and peptides. Cell labelling.
• Radiopharmaceuticals labeled with Positron Emitters. Clinical and research applications.
• Quality control of radiopharmaceuticals. Conventional vs PET. Current Good Radiopharmaceutical Practice. Analytical procedures. Process control. Microbiological tests.
• Radiopharmacy operation. European and national regulations. Work in aseptic environment. Organization of a production unit. Validation, documentation and archive.

Continuous evaluation:

Theoretical-practical evaluation with the elaboration of a monograph, in groups of 2 students, with a final oral defense with individual questions for each element of the group. Contribution of 30% for the final grade with a minimum score of 9.5/20. Final theoretical written evaluation with a contribution of 70% for the final grade and with a minimum score of 9.5/20.

Exam:

Final theoretical and theoretical-practical written evaluation with a minimum score of 9.5/20.

NAO