Base Knowledge
Não aplicável
Not applied
Teaching Methodologies
Theoretical classes aim to provide a detailed presentation of the syllabus content, using an expository and integrative methodology, with the goal of encouraging active student participation. The objective is for students to assimilate Neuroscience in an integrated manner, with a global perspective and an emphasis on health applications. During the classes, various materials will be used to offer students the opportunity to apply Neuroscience concepts through the analysis of brain pathologies. To this end, in addition to the exposition of the program, scientific articles and clinical cases relevant to the professional practice in physiotherapy will be made available to the students.
Learning Results
Teach basic concepts about the function of the central and peripheral nervous systems and the
alterations under pathological conditions. Students must:
1 identify the basic units of the nervous system and describe the organization and function of the central and
peripheral nervous systems.
2- describe the biological and molecular processes responsible for neuronal signaling and analyze its
compromise under several pathological situations.
3- analyze the mechanisms of sensory processing. Describe the physiological basis of pain and organization
and functioning of the vestibular system.
4- identify the main changes of the brain from embryonic development to adulthood.
5- analyze the process of the movement and its control and the major movement disorders.
6- demonstrate adequate capacity for synthesis and essential communication and teamwork skills
Program
1. Organization of the nervous system (NS)
1.1 Cellular components: neurons and glia
1.1.1 Cellular components – concept revision
1.1.2 Cytoskeleton and axonal transport
1.1.3 Multiple Sclerosis
1.2 Anatomy of NS
1.2.1 Structure-function relationship
1.2.2 Blood brain barrier
1.2.3 Brain imaging
1.2.2 Alzheimer’s disease and paramyloidosis
2. Neural signaling
2.1 Action potentials
2.2 Channels and transporters
2.3 Synapses
2.4 Neurotransmitters and their receptors
2.5 Intercellular signal transduction
2.6 Cerebral ischemia and Epilepsy
3. Changes in the brain
3.1 Embryonic development
3.2 Construction and modification of neural circuits
3.3 Synaptic plasticity
3.4 Schizophrenia
4. Sensation and sensory processing
4.1 Somaticosensorial system
4.2 Auditory and vestibular system
4.3 Pain
4.5 Fibromialgy
5. Movement and its central control
5.1 Circuits of the lower and upper motoneurons
5.2 Modelling of the movement by the basal ganglia and cerebellum
6.3 Parkinson’s and Huntington’s diseases, Amyotrophic Lateral Sclerosis, Ataxias
Curricular Unit Teachers
Sara Matias Carmo SilvaInternship(s)
NAO
Bibliography
Primária/Primary
Purves, Augustine, Fitzpatrick, Katz, LaMantia, McNamara, Williams (2004) “Neuroscience”, 3ª edição, Sinauer Associates Inc. ISBN 0-87893-725-0
Secundária/Secondary
Squire, Berg, Bloom, Du Lac, Ghosh, Spitzer (2012) Fundamental Neuroscience (4ª edição), Elsevier. ISBN 978-0-12-385870-2
Brady, Siegel, Albers, Fisher, Price (2011) “Basic Neurochemistry: Molecular, Cellular and Medical Aspects”, 8ª edição, Elsevier. eBook ISBN: 9780080959016
Nadeau, Ferguson (2004) “Medical Neuroscience”, 1ª edição, Saunders – Elsevier. ISBN 10: 1416024042
Matthews GG (2001) “Neurobiology: Molecules, Cells and Systems”. Blackwell Science, Inc. ISBN 0865424047