Molecular and Cellular Biology

Teaching Methodologies

The theoretical classes are aimed at the detailed presentation of the program contents. Use an expository-active methodology, appealing the direct intervention of the students, using the expected image support, where schemes and images of cellular structures will be presented and explained to the students interactively privileging the bidirectionality of the communication.
The evaluation will be done by conducting 2 evaluation moments, one of which is written and/or examination, as well as the presentation of a written work on a topic of the curricular unit.

Learning Results

The student must acquire knowledge of:
• Cell Organization
• History and evolution of knowledge of the cell.
• Differences between the two types of cell organization – prokaryotic and eukaryotic cells.
• Cellular Physiology.
The student must acquire skills:
• Identification of cellular components and organelles.
The student must acquire competences of:
• Description of cellular structures with knowledge of their normal physiology.
• Understanding of structural and physiological cellular changes underlying situations of disease.

Program

-Introduction to the study of cell biology – contributions to its development
-Overall view of the cell
-The prokaryotic versus eukaryotic cell
-The cytoplasmic membrane, its constituents and organization
-Differentiations of the cytoplasmic membrane, cell interactions and cell adhesion molecules
-Transmembrane transport by simple diffusion, facilitated and by active transport
-Membrane potential
-Generation of action potential and its spread
-Neurotransmission, Receptors and cholinergic, glutamatergical and gabaergic ways. Nitric oxide, its functions and
biological importance
-Cytoskeleton constituents, functions and cellular dynamics
-Endoplasmic reticulum, types, features and functions
-Protein synthesis and addressing
-Golgi complex, training and function of lysosomes
-Peroxisomes, biogenesis and peroxisomal metabolism
-Mitochondria, bioenergetics and biogenesis mitochondrial
-Nuclear Organization
-Activation and signalling cell
-Oxidative Stress

Internship(s)

NAO

Bibliography

Azevedo C.; Sunkel Claudio E. (2012). Biologia Celular e Molecular . 5ª ED., Lidel – edições técnicas.
De Robertis (2006). Bases da Biologia Celular e Molecular. 4ª edição – Guanabara Koogan
Lodlish; Berk; Matsudaira; Kaiser; Krieger; Scott; Zipursky; Darnell (2005). Biologia Celular e Molecular. 5ª edição – Artmed.