Teaching Methodologies
Theoretical Component:
– Using the expository method, the essential concepts of each block will be introduced, stimulating student-teacher interaction. Student-centered approaches will promote reflection and analysis of articles leading to the application of theoretical knowledge. Appropriate audiovisual media and online platforms will be used in order to facilitate the learning process. Evaluation will be continuous with two moments of interim evaluation (10/20v).
Examinations according to academic calendars.
Practical Theoretical Component:
– Learning will be action-oriented, through the resolution of current challenges focused on pathologies for which there are still no effective solutions. Groups of 3 students will have to make a critical reflection of scientific articles and present a solution and its application. The teacher will assume a facilitating role by creating an environment for learning.
The Assessment will be continuous poured into 2 proposed challenges (10/20)
Learning Results
This course will provide current state-of-the art in the field of Pharmaceutical Biotechnological drugs and by the end students will be able to:
– Integrate and apply the acquired knowledge in emerging areas of Molecular Biotechnology and biotechnological processes, particularly in the field of biopharmaceuticals applied to human health;
– Be able to suggest accurate methodologies for biopharmaceuticals production and the design of new therapeutic strategies based on multidisciplinary and complex methodologies while integrating problem-solving skills;
– Jointly group dynamics to solve the proposed challenges, will allow the student to develop scientific and
technological reasoning, as well as oral and written communication skills while employing the correct terminology.
Ultimately this will enhance collaborative and critical thinking skills.
Program
1. Introduction
1.1 Concepts of Molecular Biotechnology and Bioprocesses
1.2. Biopharmaceuticals Vs conventional drugs
2. Processes for obtaining biopharmaceuticals and their applicability
2.1 Production of recombinant proteins;heterologous expression prokaryotic and eukaryotic systems;Protein
engineering; site-directed and combinatorial mutagenesis
2.2. Blood factors,hormones,growth factors,cytokines, enzymes,monoclonal antibodies
2.3 Controlled release systems
3. Vaccine Production
3.1. Inactivated/live-attenuated
3.2. Purified proteins/polyssacharides
3.3. Recombinant proteins/nucleic acids
4. Gene therapy
4.1 Viral/ non-viral vectors
4.2 Introduction/replacement of genes; gene expression modulation
4.3 Zinc Fingers, Talen, CRISPR/Cas9/Nucleic acid-mediated gene repair
5. Cell therapy and tissue engineering
5.1. Stem cells (SC): potential and applicability
5.1.1. Embryonic and Induced Pluripotent SC
5.1.2. Multipotent SC
6. Biomaterials
6.1. Definition
6.2. Types and application
Internship(s)
NAO
Bibliography
Advances in Pharmaceutical Cell Therapy – Principles of Cell-Based Biopharmaceuticals https://doi.org/10.1142/9240 | November 2015. By (author): Christine Günther, Andrea Hauser and Ralf Huss ISBN 978-981-4616-78-2
Cell Therapy – Current Status and Future Directions. Editors – Dwaine F. Emerich; Gorka Orive. DOI https://doi.org /10.1007/978-3-319-57153-9. Springer International Publishing AG 2017. Humana Press, Cham. ISBN 978-3-319-57152-2
Biomaterials Science (Fourth Edition) – William R. Wagner, Shelly E. Sakiyama-Elbert, Guigen Zhang, Michael J.
Yaszemski, Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons. Academic Press,2020. ISBN
9780128161371. DOI: https://doi.org/10.1016/B978-0-12-816137-1.05001-7.