Analytical Chemistry

There is no recommended background knowledge.

Lecture by the teacher of contents related to the theoretical aspects of this curricular unit, as well as interactive theoretical-practical classes that aim not only to transmit knowledge, but also to understand, interpret and apply them in concrete situations.

At the end of this course the student should be able to:

• Acquire the theoretical foundations of sample preparation, preparation and standardization of solutions and sample treatment for chemical analysis

• Analyze calibration curves and establish their application limits

• Determine the precision and accuracy of analytical results and critically interpret them.

1. The Analytical Process. Sampling. Sample preparation. Principles of analytical measurement.
2. Statistical evaluation of analytical results. Accuracy and precision of analytical observations and measurements. sensitivity concept,
selectivity and specificity. Systematic and random errors. Uncertainty concept. Notion of population, sample, variable and data
statistical. Notion of outlier. Variance and standard deviation. Statistical quality control tests.
3. Calibration in Analytical Chemistry. General fundamentals of calibration. Regression and calibration. Linear calibration errors. Statistical tests and
calibration validation. Alternative procedures to calibration.
4. Presentation, interpretation and validation of analytical results. Presentation of analytical results. Interpretation of results
analytics. Presentation of results close to the limit of detection. Interlaboratory studies. Chemometric data interpretation
analytics.

NAO

Douglas C. Montgomery (1997). Design and analysis of experiments (4rd ed). New York [etc.]: John Wiley & Sons, cop. (Disponível na Biblioteca do ISEC: ISBN 0-471-15746-5)
Relacre (1996). Guia RELACRE 3: Validação de Resultados em Laboratórios Químicos. Lisboa: Relacre. (Disponível no NONIO IPC)
Relacre (2000). Guia RELACRE 13: Validação de Métodos Internos de Ensaio em Análise Química. Lisboa: Relacre. (Disponível no NONIO IPC)
NP EN ISO/IEC 17025 (2005). Requisitos gerais de competência para laboratórios de ensaio e calibração. (Disponível no NONIO IPC)
Peter C. Meier, Richard E.Zund (1993). Statistical methods in analytical chemistry. New York: John Wiley. (Disponível na Biblioteca do ISEC: ISBN 0-471-58454-1)
IPAC – Instituto Português de Acreditação (2010). OGC001 – Guia para aplicação da NP EN ISO/IEC 17025 (Disponível no NONIO IPC)
Recursos didáticos usados na lecionação: Apontamentos e folhas de exercícios elaborados pelos docentes.