Base Knowledge
Not applicable.
Teaching Methodologies
The teaching method will be mainly expository, using audiovisual means such as videos and animations, to illustrate complex concepts, demonstrate cellular processes and highlight practical examples. For Histology, practical examples of microscopic preparations for each tissue will be provided, in order to facilitate the acquisition of knowledge. These visuals will help make information more accessible while encouraging active student participation.
In addition, students will also be encouraged to study independently and conduct complementary research on the contents exposed, using resources such as books, scientific articles and online materials from verified sources.
Learning Results
The discipline of Cell Biology and Histology aims to provide students with an in-depth understanding of the structure, function and organisation of cells and tissues that constitute living organisms.
Understand the basic principles about cell structure, tissue organisation, and the relationship between structure and function.
Ability to distinguish structure and function of different tissues: describe the different types of tissues, understanding their distinct characteristics and specific functions.
Apply the knowledge acquired in practical contexts, such as the understanding of physiological processes, interpretation of histological images and correlation between structure and function in the organs and systems of the human body.
Interpretation of histological images: Students will learn to interpret and analyse histological preparations, correlating this information with the structure and function of the tissue.
Critical thinking and problem solving applied through the analysis of clinical cases, integrating taught knowledge to understand complex biological issues.
Program
Introduction to Cell Biology and Histology (2h)
1. Basic concepts of cells, tissues, organs and systems
Cell Structure and Functioning (10h)
1. Chemical composition of the cell
2. Eukaryotic cell organization
3. Intracellular compartments: smooth and rough endoplasmic reticulum, Golgi complex, lysosomes, mitochondria and nucleus
4. Structure and function of the nucleus: nuclear envelope, chromatin, chromosomes, nucleolus and ribosome synthesis
5. Chemical composition and function of the cytoskeleton
Biomembranes, Cellular Transport and Cellular Communication (4h)
1. Composition and structural organization of biomembranes
2. Functions of biomembranes
3. Membrane transport mechanisms: endocytosis and exocytosis
4. Intercellular and intracellular communication
5. Membrane potential and nerve impulse transmission
Cell Death and Regeneration (2h)
1. Apoptosis and Necrosis: concept and mechanisms
2. Regeneration and healing of tissues
Animal Tissues (6h)
1. Epithelial Tissue: characteristics, classification and functions
2. Connective Tissue: types, extracellular matrix and functions
3. Muscle Tissue: types, structure and contractile function
4. Nervous Tissue: structure, composition and functions
5. Adipose, blood and cartilaginous tissue: structure and functions
Histology of Organs and Systems (4h)
1. Digestive System: structure and functions of the organs involved
2. Respiratory System: structure and functions of the organs involved
3. Circulatory System: structure and functions of the organs involved
4. Urinary System: structure and functions of the organs involved
Curricular Unit Teachers
Internship(s)
NAO
Bibliography
Primary Bibliography:
deRobertis, E.M. Biologia Celular e Molecular. Lisboa: Fundação Calouste Gulbenkian, 1996.
Azevedo, C. Biologia Celular e Molecular. Lisboa, Porto, Coimbra : Lidel, cop.1999
Alberts, B. Molecular biology of the cell. New York : Garland Science, cop. 2008
Wheater, P. R., Burkitt, H. G., Daniels, V. G. Functional histology : a text and colour atlas. Edinburgh [etc.] : Churchill Livingstone, 1979
Kierszenbaum, A. L. Histology and cell biology : an introduction to pathology. Philadelphia : Mosby Elsevier, 2007
Secondary Bibliography:
Junqueira, L.C., Carneiro, J.. Biologia Celular e Molecular, 9ª edição. Rio de Janeiro: Guanabara Koogan, 2012.
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. Molecular Biology of the Cell, 4ª edição. New York: Garland Science, 2017.
Lodish, H., Berk, A., Zipursky, S.L., Matsudaira, P., Baltimore, D., Darnell, J. Molecular Cell Biology. New York: W. H. Freeman and Company, 2008.
Cooper, G.M. The Cell: A Molecular Approach, 8ª edição. Sunderland, MA: Sinauer Associates, 2019.
Carneiro, J., Junqueira, L.C. Histologia Básica, 13ª edição. Rio de Janeiro: Guanabara Koogan, 2017.
Pawlina, W., Ross, M.H. Histology: A Text and Atlas With Correlated Cell and Molecular Biology, 8ª edição. Philadelphia: Wolters Kluwer. 2018
DiFiore, M.S. diFiore’s Atlas of Histology With Functional Correlations, 12ª edição. Philadelphia: Lippincott Williams & Wilkins, 2014.