Chemical and Biological Reactors

Good background in Mathematics and Thermodynamics

In the lectures are presented for the first time, the syllabus of the course, using the projection of slides and, whenever possible, the resolution of exercises for application. In practical classes, the teacher guides the student in solving a wide range of exercises covering all components of the curriculum. The proposed problems to be solved are distributed to the students in advance.

The learning outcomes of this course pass through to provide students with the ability to:
– determine a simple kinetic equation, by applying the integral method of data analysis;
– design and analyze the operation in a constant-volume ideal reactor, in isothermal operation;
– design and to analyze the operation of an ideal reactor for non-isothermal operation (CSTR in adiabatic or not adiabatic operation and DSTR and PFR in adiabatic operation);
– use the Michaelis-Menten equation and Monod equation;
– evaluate the type of inhibition in a enzymatic reaction;
– design and to analyze an ideal reactor (DSTR and CSTR) for enzymatic and microbial reactions, in isothermal operation.

1. Kinetics of homogeneous reactions. Constant-volume batch reactor. Integral method of anslysis of data and
aplication to the following reactions: irreversible unimolecular-type first-order reactions; irreversible bimoleculartype second-order reactions and irreversible trimolecular-type second-order reactions. The half-life method.
2. Mole balances on ideal reactors. Non-isothermal ideal reactors. The energy balance. Adiabatic operation (DSTRs, CSTRs and PFRs). Non adiabatic operation (CSTRs)
3. Enzyme fermentation. Michaelis-Menten equation. Lineweaver-Burk equation Inhibition of enzime reactions. Competitive inhibition, uncompetitive inibition and noncompetitive inhibition. Application to ideal reactors.
4. Stoichiometry and kinetics of microbial processes. Cell growth, cell death, cell maintenance, substrate consume, and product formation. Luedeking-Piret equation. Mass balances on batch and chemostat operation. Application to ideal reactors.

• - exame - 100.0%

• - CF = (Avaliação 1 + Avaliação 2 + Avaliação 3 + Avaliação 4 + Avaliação 5) / 5 - 100.0%

NAO

   Missen, M.S., “Introduction to Chemical Reaction Engineering”, John Wiley & Sons, inc., New York, 1999.

   Schmidt, L.D. “The Engineering of Chemical Reactions”, 2ª ed., Oxford University Press, Oxford, 2004.

   James, E.B., David, F.O., “Biochemical Engineering Fundamentals”, 2ª ed., Mc Graw-Hill, 1986.

   Levenspiel, O., “Chemical Reaction Engineering”, 3ª ed., John Wiley & Sons, New York, 1999.

   Froment, G.F., Bischoff, K.B., De Wilde J., “Chemical Reactor Analysis and Design”, 3ª ed., John Wiley, 2010.

   Lemos, F., Lopes, J.M., Ribeiro, F.R., “Reatores Químicos”, 3ª ed., IST Press, Lisboa, 2014.

   Dunn, I.J., Heinzle, J.I., Prenosil, J. E., “Biological Reaction Engineering: Dynamic Modelling Fundamentals with Simulation Examples”, 2ª ed., VCH Publishers, New York, 2003.

   Fonseca, M., Teixeira, J., “Reatores Biológicos – Fundamentos e aplicações”, 1º ed., Lidel, 2007.

   Fogler, H.S., “Essentials of Chemical Reaction Engineering”, International edition, Prentice Hall, 2011.