Clinical and Laboratory Diagnosis in Oncobiology

Cellular and Molecular Biology, Immunology, Morphological Pathology, Biochemistry,

Expository method using audiovisual media. It also includes an autonomous study with research on the exposed contents.

To understand the concept of neoplasia as alteration of growth and differentiation of cells / tissues;

Recognize the main types of human neoplasia, their geographical distribution and temporal evolution; Identify
the main phases of neoplastic development and the agents involved in this process; Recognize the foundations
molecular / genetic factors underlying the process of tumorogenesis; Recognize the process of tumorogenesis as
interaction between organism and environment; Recognize and understand the main associated hereditary conditions
cancer; Know the therapies used to fight cancer; Know the main techniques used in
Oncobiology.
Understand the basic mechanisms of therapy aimed at molecular targets; Recognize the main
fields and lines of research in Oncobiology

• Epidemiology;
• Biology of tumor growth;
• Molecular bases of cancer;
• Classification of tumors;
• Hallmarks of cancer;

Application of the different laboratory approaches for the diagnosis and monitoring of the contents mentioned below in cancer:
• Intercellular communication and signal transduction pathways;
• Cell proliferation and proteins that regulate cell proliferation;
• Angiogenesis;
• Apoptosis;
• Carcinogens;
• Phases of tumor growth;
• Invasion and Metastasis;
• Tumor stem cells;
• Tumor markers;
• Therapeutics: proteins as a therapeutic target;
• Resistance to therapy.

NAO

Primary reference

– DEVITA, Vincent T., Jr.; LAWRENCE, Theodore S.; ROSENBERG, Steven A., ed. lit. – Devita, Hellman, and Rosenberg’s cancer: principles & practice of oncology. 10th edition. Philadelphia, [etc.]: Wolters Kluwer, cop. 2015. xiv, 2234 p. ISBN 978-1-4511-9294-0

– ABELOFF, Martin D., ed. lit. – Abeloff’s clinical oncology. 4th ed. Philadelphia, PA: Churchill Livingstone / Elsevier, cop. 2008. xxx, 2555 p. ISBN 978-0-443-06694-8

– DAVIES, A. M.; SUNDARAM, M.; JAMES, S. L. J.; ANDERSON-SEMBACH, S.; BAERT, A. L., ed. lit. Imaging of bone tumors and tumor-like lesions: techniques and applications. Berlin; Heidelberg: Springer, cop. 2009. XII, 698 p. ISBN 978-3-540-77982-7

– KOSS, Leopold G.; ; MELAMED, Myron R., ed. lit. – Koss’ diagnostic cytology and its histopathologic bases. 5th ed. Philadelphia; Baltimore: Lippincott Williams & Wilkins, cop. 2006. 2 vol. (xviii, 1752, I-52 p.). ISBN 978-0-7817-1928-5.

Secondary reference

– PECORINO, Lauren – Molecular Biology of Cancer: Mechanisms, Targets and therapeutics. 3rd edition

– Hanahan, D.; Weinberg, R.A. The Hallmarks of Cancer. Cell 2000, 100, 57–70, doi:10.1016/S0092-8674(00)81683-9.

-Hanahan, D.; Weinberg, R.A. Hallmarks of Cancer: The Next Generation. Cell 2011, 144, 646–674, doi:10.1016/j.cell.2011.02.013.

– Soerjomataram, I.; Bray, F. Planning for tomorrow: global cancer incidence and the role of prevention 2020–2070. Nat. Rev. Clin. Oncol. 2021, 18, 663–672, doi:10.1038/s41571-021-00514-z.