Clinical-Laboratorial Biochemistry I

Knowledge of general biochemistry, chemistry and cell biology.

The theoretical classes are aimed at the detailed presentation of the program contents. Use an
expositoryactive methodology, appealing the direct intervention of the students.
In the practical component part of the curricular unit it’s privileged the execution of practical laboratory
assignments, explanations and discussion of clinical cases.

The student must acquire knowledge of:
• Theoretical foundations underlying the metabolism of carbohydrates, amino acids and proteins;
• Laboratory parameters indicated for the diagnosis and monitoring of pathologies associated with
alterations of metabolism.
The student must acquire skills:
• Understand the laboratory parameters indicated for the diagnosis and monitoring of pathologies
associated with metabolic changes, in order to be possible to provide clinically relevant laboratory
information;
The student must acquire competences of:
• Understand the various pathologies associated with changes in the metabolism of carbohydrates,
aminoacids and proteins;
• Select the laboratory parameters indicated in diagnosis and/or monitoring of these pathologies;
• Validate and interpret critically the results obtained.

Renal function:
-Acid-base balance;
-Water-electrolytes balance;
-Endocrine Function;
-Laboratory evaluation and associated pathologies.
Metabolism of carbohydrates:
-Hypo and hyperglycaemia system;
-Diabetes and its acute complications and chronic;
-Laboratory Assessment and associated pathologies.
Amino acids metabolism:
-Laboratory evaluation and associated pathologies. Protein metabolism:-specific proteins;
-Laboratory evaluation of hepatic function and associated pathologies;
-Laboratory evaluation of muscle and heart diseases.

NAO

Primary bibliography:

Ahmed, Nessar, ed. lit. – Clinical biochemistry. Second edition. Oxford : Oxford University Press, cop. 2017.

Burtis, CA; Bruns, DE, Sawyer, BG, Tietz, NW. Tietz fundamentals of clinical chemistry and molecular diagnostics. seventh edition. ed. St. St. Louis, Mo: Elsevier/Saunders, cop. 2015.
Gaw, Alan et al – Clinical Biochemistry: An Illustrated Colour Text. 5th ed. Churchill-Livingstone Elsevier, 2013.

Kaplan, Lawrence; Pesce, Amadeo – Clinical Chemistry: Theory, Analysis, Correlation: With 509 Illustrations and 25 Color Plates. 5th ed. St. Louis, Mo.: Mosby/Elsevier, 2010.

Secondary bibliography:

Murphy, Michael, et al – Clinical Biochemistry: An Illustrated Colour Text. 6th ed. Churchill-Livingstone Elsevier, 2019.

Rifai, N., et al., Tietz fundamentals of clinical chemistry and molecular diagnostics. Eighth edition. ed. St. Louis, Missouri: Elsevier, 2019.

Bishop, M.L., E.P. Fody, and L.E. Schoeff, Clinical chemistry : principles, techniques, and correlations. Eighth edition. ed. Philadelphia: Wolters Kluwer, 2018.

Mcpherson, Richard; Pincus, Matthew; Henry, John – Henry’s Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia: Saunders Elsevier, 2011.

Devlin, Thomas M – Textbook of Biochemistry with Clinical Correlations. 7th ed.: Wiley, 2010.