Base Knowledge
Previous knowledge in Immunology, particularly, which are the cells of the immune system and their function, since they also took part of the hematopoietic system.
Knowledge in molecular biology, since PCR and NGS are crucial techniques for the diagnosis and prognosis of hematological malignancies.
Knowledge in cellular biology.
Teaching Methodologies
The main goal of theoretical classes is to present in detail all the different parts of the program. During the classes, graphic exposition, based on powerpoint presentations, will be used to allow a better acquisition of knowledge by the students, as well as a good interaction between the students and the teacher.
During the theoretical-practical part of the Hematology classes, it will be emphasized the case analysis involving different techniques, such as morphology, immunophenotyping, genetic abnormalities analysis and blood counts, which will allow the students to purpose a possible diagnosis for the different hematological diseases and the subsequent classification according to the World Health Organization classification system.
Learning Results
The student should acquire the knowledge of:
•Normal Hematopoiesis and their regulation.
•Malignant hematopoietic disorders: Etiology, Physiopathology, WHO classification, Diagnosis methods, prognosis and treatment monitoring.
•Laboratory methods in Hematology: Hematimetric parameters, morphology, phenotype, molecular biology, conventional cytogenetic and fluorescence in situ hybridization.
The student should acquire the faculty of:
•Well known the normal and malignant hematopoiesis.
The student should acquire the skills to:
•Develop, retain and expand their knowledge in the Hematology field.
•Know the different WHO entities, starting in the etiology of each disease, physiopathology and clinical and biological characteristics.
• Know the laboratorial methodologies more often used to do a correct diagnosis of the different hematological neoplasm and to analyze the obtained results in normal or pathological conditions.
Program
Hematological malignancies overview: The importance of the lab for diagnosis, prognosis and treatment monitoring of hematological disorders.
Hematimetric parameters: normal and abnormal values and their correlation with different disorders
Normal hematopoiesis: Phenotypic and morphological changes during the maturation process in all hematological lineages.
B, T and NK chronic lymphoproliferative disorders: Etiology; physiopathology; molecular, phenotypic and morphological diagnosis. Treatment.
Monoclonal gammopathies: Etiology; physiopathology; molecular, phenotypic and morphological diagnosis. Treatment.
B or T acute lymphoblastic leukemia’s: Etiology; physiopathology; molecular, phenotypic and morphological diagnosis. Treatment.
Acute myeloblastic leukemia’s and other acute leukemia’s: Etiology; physiopathology; molecular, phenotypic and morphological diagnosis. Treatment.
Dendritic cells neoplasm: Etiology; physiopathology; molecular, phenotypic and morphological diagnosis. Treatment.
Curricular Unit Teachers
Internship(s)
NAO
Bibliography
Primary:
Hoffbrand, A. V., P. A. H. Moss, and J. E. Pettit. Essential Haematology. 6th ed. Malden, Mass.: Wiley-Blackwell, 2011
Hoffbrand, A. V., J. E. Pettit, and Paresh Vyas. Color Atlas of Clinical Hematology. 4th ed. Philadelphia, Pa.:
Mosby/Elsevier, 2010
Kaushansky, Kenneth, and William J. Williams. Williams Hematology. 8th ed. New York: McGraw-Hill Medical, 2010.
Lewis, S. M., Barbara J. Bain, Imelda Bates, and John V. Dacie. Dacie and Lewis Practical Haematology. 10th ed.
Philadelphia: Churchill Livingstone/Elsevier, 2006.
Secondary:
Artigos científicos que abordam assuntos da parte teórica que não estão presentes nos livros recomendado