Metabolism and Radiobiology in Medical Imaging and Radiotherapy

In this curricular unit, the general structure of teaching methodologies will be theoretical with the application of knowledge, skills and competences to practical reasoning in the area of Medical Imaging and Radiotherapy.
The assessment will be carried out by written test.

Provide students with the tools to understand the aspects underlying the use of new radiotracers, which includes the characterization of the different underlying metabolic pathways and their impact on the clinical practice of medical imaging and radiotherapy.
Identify individual factors and biomarkers that condition the response to radiation
Understand the role of omics technologies in the practice of medical imaging and radiotherapy, which includes
lipidomics, proteomics, genomics and metabolomics.
Identify and understand the constituents in the microenvironment that influence the response to radiation.
Apply the acquired knowledge to the clinical practice of medical imaging and radiotherapy.

1. Radiotracer kinetics, metabolism and new molecules in imaging and therapeutics
2. Metabolism and precision medicine in medical imaging and radiotherapy
a. Metabolism and spectroscopy imaging
b. Radiomics
3. Omic Technologies in Medical Imaging and Radiation Therapy
a. Proteomics
b. Lipidomics
c. Metabolomics
4. Sensitivity to individual radiation and biomarkers
a. Exposure Biomarkers
b. Susceptibility Biomarkers
c. Late Effects Biomarkers
d. Persistent Effects Biomarkers
e. The influence of different pathologies on the radiation response
f. Predictive Assays
5. Microenvironment and radiation response
a. Low dose modifications and High dose limitations
b. Radiobiology models for normal tissue toxicity
c. 6R’s (repair, Redistribution, Repopulation, Re-oxygenation, Reactivation of Immune system, radiosensitivity)
d. Microbiome and radiation therapy

NAO

Basic Clinical Radiobiology. M Joiner and A van der Kogel. Hodder Arnold, 2009
Basic Radiation Oncology. M Beyzadeoglu, G Ozyigit and C Ebruli. Springer, 2010
Omics Applications for Systems Biology, Springer 2018
Radiomics and Its Clinical Application, Elsevier 2021