Processes Principles in Bioengineering

Chemistry and Mathematics.

The theoretical classes are intended to expose the syllabus of the course accomplished with illustrative examples of applications. The theoretical practices classes are used for solving problems and exercises. In these classes, after a general discussion of the specific problems, students are encouraged to continue with the corresponding resolutions complemented with a general discussion of the obtained results. The proposed problems to be solved are distributed to the students in advance. 

The main objective of the curricular unit is to provide the student with the necessary knowledge to implement calculations in chemical/biotechnological processes, using the principles of mass and energy conversion. Thus, it is intended that students are able to i) carry out mass balances of chemical and biological processes without and with reaction and assimilate notions of inventory variation, by-pass, recycling and purging; ii) use the psychrometric chart using the concepts of dry and humid temperatures, dew point, absolute, relative and molar humidity; iii) carry out energy balances for chemical and biological processes.

1. IDEAL GASES

Ideal gas law. Standard pressure and temperature conditions. Average molar mass, volumetric mass and density of gases.

2. MASS BALANCES

The concept of mass balance. Selection of a calculation basis in mass balance problems. Balances in processes without chemical/biological reactions.

Chemical reactions, biological reactions, stoichiometry and stoichiometry of cell growth and product formation. Limiting reagent. Stoichiometric excess of a reactant.

Mass balances in systems with chemical/biological reactions.

Mass balances in processes with bypass, product and/or inert recycling and purging.

3. THE AIR-WATER SYSTEM

Relationship between saturation and humidification state. Ways to express the composition of a vapor in a gas mixture: molar humidity, percentage of moisture and percentage of relative humidity. Use of saturated vapor tables to solve humidification exercises.

Use of the psychometric chart in solving humidification exercises.

4. ENERGY BALANCES

General energy balance equation. Calculation methodology for energy balances.

Amount of heat involved in heating/cooling with and without phase change.

Energy balances in processes with chemical/biological reactions.

NAO

Bibliografia principal

Moreira, M. J. (2023). Apontamentos de Introdução aos Processos em Bioengenharia. ISEC (disponível na plataforma académica InforEstudante).

Bibliografia complementar

Doran, P. (2012). Bioprocess Engineering Principles. Elsevier.

Bailey, J.E., Ollis, D.F. (1986). Biochemical Engineering Fundamentals: McGraw-Hill. ISBN 0-07-066601-6 (Disponível na Biblioteca do ISEC: 6-13-18)

Ghosh, R. (2006). Principles of Bioseparations Engineering. World Scientific Publishing. https://doi.org/10.1142/6183

Himmelblau, D.M.; Riggs, J.B. (2012) Basic Principles and Calculations in Chemical Engineering, 8th edition.

Seider, W.D., Seader, J.D., Lewin, D.R. (2008). Product and process design principles. SBN: 0-471-45247-5 0471203165.

Sirohi, R., Pandey, A, & Taherzadeh, M. J. (Eds). (2022). Current Developments in Biotechnology and Bioengeneering: Advances in Bioprocess Engineering. Elsevier. https://doi.org/10.1016/C2020-0-04191-5