Technology and Galenic Pharmacy II

Basic notions of safety in a laboratory environment;

Basic rules and techniques of laboratory work;

Knowledge of material and equipment in common use in laboratories;

Knowledge of standards for weighing and measuring volumes and temperature of liquids;

Elementary knowledge of mechanical operations of separation and division of solids.

T and TP lectures using audiovisual and interactive means between students and teacher.Demonstrative and active practical classes with interpretation and execution of some techniques that lead to the preparation,packaging and labeling of medicines. Application of some control procedures for the prepared dosage forms.

At the end, students must master the terminology, concepts and technical-scientific aspects inherent to medicines and pharmaceutical technology of dosage forms. It is intended to enable the student with fundamental knowledge about the pharmaceutical forms addressed in relation to the operations to which the substances are subjected, the properties of the products used, the composition, application and preparation procedures and quality control. In the practical component, the student must be able to autonomously apply rational and scientific methods for the formulation and preparation of dosage forms, to interpret the formula, to know how to associate the substances, the incompatibilities that may arise and the fundamental aspects of labeling , conservation and storage of the prepared formulas. Know the main pharmaceutical forms suitable for modifying the release of drugs and their important therapeutic and/or diagnostic applications.

Pharmaceutical forms obtained by molecular dispersion: solutions and syrups. Pharmaceutical forms obtained by dissolution and evaporation: extracts. Pharmaceutical Forms obtained by complex or multiple operations: for application to the skin (ointments, creams, pastes, gels or ointments-jelly, liniments, lotions, soaps, plasters and transdermal preparations), for auricular use, for rectal application (suppositories, enemas) , for vaginal application (eggs, vaginal tablets), for ophthalmic use (ophthalmic ointments, eye drops), for nasal use, for urethral use and for parenteral use (injectable preparations). Pharmaceutical operations, production technologies, laboratory and industrial equipment, biopharmaceutical aspects, stability and quality control. Excipients. Labelling, packaging and storage conditions. Controlled release pharmaceutical forms: concepts, requirements and advantages. Liposomes, nanoparticles, microencapsulation, micelles and microemulsions.

NAO

Primary:

Farmacopeia Portuguesa IX. INFARMED. 2009
Tecnologia farmacêutica – L. N. Prista, A. C. Alves, R. M. R. Morgado, vol. I, II, III – Fundação Calouste Gulbenkian
Formulário Galénico Português. ANF. 2005.

Remington – A Ciência e a Prática da Farmácia. Alfonso R. Gennaro. 20ª Edição.
Guia Prático da Farmácia Magistral: Farmacotécnia, Boas práticas de manipulação, Controle de Qualidade, Aspectos
Biofarmacêuticos, Excipientes e veículos, Procedimentos operacionais padrão. Anderson de Oliveira Ferreira, 2ª
Edição, Pharmabooks

Martindale – The Complete Drug Reference”. 37ª Edição. Pharmaceutical Press, 2011.

Secondary:

Handbook of Pharmaceutical Excipients. RC Rowe, PJ Sheskey and SC Owen (Eds.), Pharmaceutical Press, London,
2006.
Teoria e Prática na Indústria Farmacêutica. I e II Volume. Serviço de Educação e Bolsas. Fundação Calouste
Gulbenkian. Leon Lachman; Herbert A. Lieberman; Joseph L. Kanig
Jain K: The Handbook of Nanomedicine: Humana Press; 2012.