Biochemistry and Molecular Biology

Students must have knowledge of Organic Chemistry, namely the structure of functional groups and stereochemistry.

Theoretical classes will be oriented towards the understanding of the theoretical foundations of the curricular unit, being complemented with theoretical-practical classes for the resolution of questions. In the theoretical classes the exposition of the subject will be made through the use of a slide projection system in powerpoint and some active learning methodologies will be applied, namely the flipped learning and the use of collaborative tools such as the jamboard. In the theoretical-practical classes, worksheets on the different chapters taught will be solved. Students are encouraged to participate during theoretical and theoretical-practical classes. At the end of the theoretical-practical classes, the answers to the proposed questions and the framed topics will be discussed. All study material will be made available through the “Inforestudante” platform.

The main objective of this course is to provide students with the fundamental concepts of Biochemistry and Molecular Biology. It is intended thus, that the students be able to: i) characterize the structure and function of the main biological macromolecules; ii) adequately communicate the knowledge acquired about cellular metabolism; iii) Identify the main processes of regulation and control of metabolic pathways; iv) describe the various processes of storage and expression of genetic information in the cell.

1. Review of Organic Chemistry concepts. Functional groups and Stereochemistry.

2. Biological macromolecules: Aqueous medium, solubility and pH. Structure and function of biological macromolecules. Proteins,  carbohydrates, lipids and nucleic acids.

3. Cellular metabolism and regulation.

 4.Molecular Biology.

• - Exame - 100.0%

• - Execução de mini-testes escritos periódicos - 100.0%

NAO

Recommended bibliography:

 1. Campos, L.S. (2009). Entender a Bioquímica. 5ª edição. Lisboa: Escolar Editora. (6-15-24 (ISEC) – 14151).

 2. Halpern, M., Freire, A. e Quintas, A. (2008). Bioquímica: Organização Molecular da Vida. Lisboa: Lidel. (6-15-30 (ISEC) – 14439).

 3. Hoboken, N.J. (2006). Concepts in biochemistry. 3ª edição. John Wiley & Sons. (6-15-25 (ISEC) – 14167).

Complementary bibliography:

 1. Nelson, D. and Cox, M. (2012). Lehninger Principles of Biochemistry. 6th edition. New York: W.H. Freeman and Company.

 2. Elliott, W. and Elliott, D. (2008). Biochemistry and Molecular Biology. 4th edition. Oxforf University Press.

 3. Murray, R., Granner, D. e Rodwell, V. (2010). Harper Bioquímica Ilustrada. 28ª edição. New York: Mc Graw Hill.