Base Knowledge
Previous knowledge in Immunology, particularly, which are the cells of the immune system and their function, since they also took part of the hematopoietic system.
Knowledge in molecular biology, since PCR and NGS are crucial techniques for the diagnosis and prognosis of hematological malignancies.
Teaching Methodologies
The theoretical classes are aimed at the detailed presentation of the program contents. Use an expository-active
methodology, appealing the direct intervention of the students, favouring openly an abundant iconography instead
of the detriment of a theoretical-descriptive teaching.
In the practical approach of the teaching of Hematology will be focusing on the analysis of cases involving
morphology, hematimetric parameters, platelets counts and coagulation studies, which will allow the students to
purpose a potential diagnosis.
Learning Results
The student should acquire knowledge of:
• Erythropoiesis, normal megacariopoiese and its regulation .
• Myelodysplastic and myeloproliferative syndromes: etiology, pathophysiology and diagnostic methods .
• Diseases of the red blood cell: etiology, pathophysiology and diagnostic methods .
• Mechanisms of activation and inhibition in haemostasis.
The student must acquire skills :
• Knowing well the whole process of erythropoiesis and megacariopoiese .
• Laboratory evaluation of hemostasis according to study algorithms .
The student must acquire competences of:
• Develop the ability to retain and expand their knowledge in Haematology.
• Know the different pathologies of the red blood cells and platelets, biological and clinical characteristics and
changes in laboratory parameters.
• Known the laboratory methodologies most used in the Laboratory of Haematology that support the diagnosis of
diseases of the red blood cell and platelet and know how to analyze and interpret the results.
Program
Myeloproliferative and myelodysplastic syndromes: Etiology , pathophysiology , morphological , phenotypic and
molecular diagnostics. Therapy.
Anemias:
• Primary deficiency in production; aplastic anemias
• Secondary deficiencies of production: nutritional anemia
• Iron metabolism: iron deficiency anemia
Hemoglobinopathies and thalassemias
Pathologies of the red blood cell membrane : spherocytosis and other diseases of the erythrocyte membrane.
Erythrocyte metabolism and enzymopathies .
Hemolytic anemias .
Most common acquired coagulopathies – lupus inhibitor, liver failure , vitamin K deficiency and disseminated
intravascular coagulation (DIC).
Hemorrhagic diseases evaluation – platelet anomalies , von Willebrand disease , haemophilia A and B and prenatal
diagnosis.
Evaluation of thrombotic risk – deficits of natural inhibitors and SNPs associated with predisposition to thrombotic
risk .
Differential diagnosis of congenital and acquired pathology
Curricular Unit Teachers
Internship(s)
NAO
Bibliography
Primary:
Hoffbrand, A. V., P. A. H. Moss, and J. E. Pettit. Essential Haematology. 6th ed. Malden, Mass.: Wiley-Blackwell, 2011.
Hoffbrand, A. V., J. E. Pettit, and Paresh Vyas. Color Atlas of Clinical Hematology. 4th ed. Philadelphia, Pa.:
Mosby/Elsevier, 2010.
Lewis, S. M., Barbara J. Bain, Imelda Bates, and John V. Dacie. Dacie and Lewis Practical Haematology. 10th ed.
Philadelphia: Churchill Livingstone/Elsevier, 2006.
Marder, Victor J. Hemostasis and Thrombosis : Basic Principles and Clinical Practice. 6th ed. Philadelphia: Wolters
Kluwer/Lippincott Williams & Wilkins Health, 2013.